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Use Methotrexate as directed by your doctor. Check the label on the medicine for exact dosing instructions.* Take Methotrexate by mouth with or without food. However, you should take it the same way each time in relation to food.* Drinking extra fluids while you are taking Methotrexate is recommended. Check with your doctor for instructions. * Be sure you understand exactly how much of Methotrexate to take and how often you should take it. Ask your doctor or pharmacist if you have any questions. * It may take several weeks for your symptoms to improve. Do not stop taking Methotrexate without checking with your doctor.* Methotrexate works best if each dose is taken at the scheduled time.* Continue to take Methotrexate even if you feel well. Do not miss any doses.
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:* dizziness; headache; loss of appetite; mild hair loss; nausea; stomach pain or upset; tiredness; vomiting.Seek medical attention right away if any of these severe side effects occur:* Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; calf or leg pain or swelling; change in the amount of urine; chest pain; coma; confusion; coughing up blood; dark urine; diarrhea; difficult or painful urination; dry cough; fever, chills, or sore throat; menstrual changes; mental or mood changes; mouth sores; one-sided weakness; red, swollen, peeling, or blistered skin; seizures; severe or persistent nausea or vomiting; shortness of breath; speech changes; unusual bleeding or bruising; unusual pain and discoloration of the skin; unusual tiredness or weakness; vision changes or vision loss; yellowing of skin or eyes.
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